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Could the Body’s Own Defense Against ALS Actually Drive Disease Progression?

From the lab of Tom Maniatis, PhD, Columbia's Zuckerman Institute

Differences in disease progression in spinal interneurons, a type of nerve cell that generally succumbs to ALS in later stages of disease. Left: Normal ALS models, showing protein aggregation (red/green) in spinal interneurons. Right: autophagy-suppressed ALS models, showing virtually no aggregation (Credit: Tom Maniatis/Columbia's Zuckerman Institute).

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Disease September 13, 2017

Could the Body’s Own Defense Against ALS Actually Drive Disease Progression?

A new study in mice reveals that one of the body’s natural defenses against ALS suppresses disease progression early on, but in later stages advances the disease’s deadly spread through the spinal cord.

Disease September 4, 2017

The Mystery Behind Schizophrenia's Most Stubborn Symptom

New study in mice reveals biological origins of memory deficits, a core symptom of schizophrenia.

The Senses August 31, 2017

How Does Rafael Nadal Keep His Eye on the Ball? The Neuroscience of Vision

In celebration of the 2017 US Open, Columbia's Zuckerman Institute presents a piece that explores the minds behind the talents. Join us for a tour led by neuroscientist Rudy Behnia, PhD, an expert in vision at Columbia's Zuckerman Institute.

Movement August 30, 2017

Hidden Deep in the Brain, a Map That Guides Animals’ Movements

What if you could look deep into the brain and watch the activity of hundreds of neurons in a moving animal? Now, with miniature mobile microscopes, this is possible in mice and has enabled scientists to uncover a map that is used by the brain to guide our movements.

The Senses August 9, 2017

How the Tongue Keeps Its Tastes Straight

Signals sent by tongue’s taste cells prevent the brain from confusing bitter and sweet tastes.

Decision Making July 27, 2017

Scientists Witness the Brain’s ‘Aha!’ Moment

Study lends insight into one of neuroscience’s greatest puzzles: how the brain transforms unconscious information into conscious thought.

Movement July 20, 2017

How Patterns of Brain Activity Direct Specific Body Movements

Study in mice answers long-standing scientific question about the brain’s ability to drive movement

Learning & Memory June 27, 2017

Learning, Memory and Movement: Revealing Connections Behind the Brain’s Talents

Whether it’s hitting a homerun or a tickling the ivories, neuroscientist Rui Costa, PhD, investigates how we learn skilled movement — and what happens in the brain when that ability is disrupted.

Tools & Technology June 16, 2017

Building the Tools to Revolutionize Brain Research

At the 2017 World Science Festival, scientists shared their insights into how technology is advancing what we can uncover about the brain — and how that knowledge stands to improve health and society

The Senses May 22, 2017

How the Brain Turns Down the Volume on Your Noisy Body

A Q&A with Nathaniel Sawtell, PhD