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Could the Body’s Own Defense Against ALS Actually Drive Disease Progression?

From the lab of Tom Maniatis, PhD, Columbia's Zuckerman Institute

Differences in disease progression in spinal interneurons, a type of nerve cell that generally succumbs to ALS in later stages of disease. Left: Normal ALS models, showing protein aggregation (red/green) in spinal interneurons. Right: autophagy-suppressed ALS models, showing virtually no aggregation (Credit: Tom Maniatis/Columbia's Zuckerman Institute).

News from about

Disease September 4, 2017

The Mystery Behind Schizophrenia's Most Stubborn Symptom

New study in mice reveals biological origins of memory deficits, a core symptom of schizophrenia.

Learning & Memory June 27, 2017

Learning, Memory and Movement: Revealing Connections Behind the Brain’s Talents

Whether it’s hitting a homerun or a tickling the ivories, neuroscientist Rui Costa, PhD, investigates how we learn skilled movement — and what happens in the brain when that ability is disrupted.

Learning & Memory November 30, 2016

How Birds Learn to Sing — and What This Reveals About Human Communication

Why is the young brain so good at learning language?

Learning & Memory October 5, 2016

Brain Study Reveals How Teens Learn Differently Than Adults

Columbia-led research finds adolescents’ ability to remember is closely linked to reward-learning behavior.

Computation October 3, 2016

How the Brain Makes New Memories While Preserving the Old

Advance helps to resolve this long-standing scientific question; offers framework to guide future studies of memory.

Learning & Memory July 7, 2016

Imaging Study in Mice Sheds Light on How the Brain Draws a Map

Scientists track brain-cell activity of mice in real time, gain insight into how the brain stores and organizes information

Decision Making June 10, 2016

Philosophers, Brain and Mind Scientists Discuss Search for the Self

The World Science Festival concluded by addressing one of the hardest questions in science: How do our brains give rise to our sense of self?

Decision Making May 3, 2016

Finding the Beats in our Brains

What happens in the brain of a jazz musician when he or she plays a tune — and what happens in the brains of audience members when they hear it.

Learning & Memory March 10, 2016

Newborn Brain Cells Required for Memory

Columbia neuroscientists have described the activity of newly generated brain cells in awake mice and revealed the critical role these cells play in forming memories.