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Could the Body’s Own Defense Against ALS Actually Drive Disease Progression?

From the lab of Tom Maniatis, PhD, Columbia's Zuckerman Institute

Differences in disease progression in spinal interneurons, a type of nerve cell that generally succumbs to ALS in later stages of disease. Left: Normal ALS models, showing protein aggregation (red/green) in spinal interneurons. Right: autophagy-suppressed ALS models, showing virtually no aggregation (Credit: Tom Maniatis/Columbia's Zuckerman Institute).

News from about

Disease September 13, 2017

Could the Body’s Own Defense Against ALS Actually Drive Disease Progression?

A new study in mice reveals that one of the body’s natural defenses against ALS suppresses disease progression early on, but in later stages advances the disease’s deadly spread through the spinal cord.

Disease September 4, 2017

The Mystery Behind Schizophrenia's Most Stubborn Symptom

New study in mice reveals biological origins of memory deficits, a core symptom of schizophrenia.

Disease April 27, 2017

Can Tangled-Up Neurons Lead to Depression-Like Behavior?

Twin papers lend clues into how the brain organizes itself, offering new avenues for studying psychiatric disorders.

Movement February 23, 2017

Mastering New Movements

In his research, Rui Costa asks: How does the brain discover and refine new behaviors?

The Senses July 12, 2016

A Researcher Comes Face-to-Face with Sight

Ning Qian is exploring how the brain makes sense of the world we see, as well as why people with autism often find it difficult to look at faces.

Tools & Technology June 21, 2016

How are Adult and Newborn Mouse Brains Different?

Findings reveal mismatch between neuronal activity and blood flow in the brains of newborn mice, shedding new light on how the growing brain feeds itself

Franck Polleux Wins Prize for Outstanding Contributions to Neuroscience

Award recognizes Dr. Polleux’s groundbreaking research to map the brain’s wiring, lending insight into human cognition and our susceptibility to disease.

Charting the Growth of Brain Cells’ Branches

In his research, Wesley Grueber asks: How do cells know how and where to spread their tendrils?

Disease February 18, 2016

Scientists Eliminate Core Symptom of Schizophrenia in Mice

Team uses chemical compound to restore affected brain regions; findings could lead to new treatment strategies.