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Scientists Identify Gene That First Slows, Then Accelerates, ALS in Mice

From the lab of Tom Maniatis, PhD, Columbia's Zuckerman Institute

Representative confocal microscope image of the ventral horn of the spinal cord from an ALS mouse. Several microglial cells (green) infiltrate the spinal cord as ALS disease progresses. Single molecule FISH detected IRF7 (an interferon-inducible gene) RNA molecules (red) in microglia and other cells (Credit: Valeria Gerbino/Maniatis lab/Columbia’s Zuckerman Institute).

News from about

Disease March 27, 2020

Scientists Identify Gene That First Slows, Then Accelerates, ALS in Mice

Columbia study underscores complexities of deadly neurodegenerative disease; offers promising strategies to target disease’s underlying genetic mechanisms.

Disease February 19, 2020

Curious Minds: Can You Inherit Stress on Your DNA?

Do the experiences of your father leave a mark on your genes? Can trauma be passed down from generation to generation?

Disease February 6, 2020

Toxic Protein, Linked to Alzheimer’s and Other Diseases, Exposed in New Detail

Columbia-led team harnesses two powerful technologies to identify promising targets for diagnosing and treating neurodegenerative diseases.

Learning & Memory October 31, 2019

Curious Minds: Why Do Some Memories Last a Lifetime?

Mentored by Nobel laureate Eric Kandel, two young scientists team up and discover they have a lot in common.

The Senses October 21, 2019

How the Brain Dials Up the Volume to Hear Someone in a Crowd

Columbia-led study offers new insight into organization of brain’s listening center; provides roadmap for development of hearing-aid technologies inspired by the brain

Disease October 21, 2019

Rui Costa Elected to the National Academy of Medicine

Academy recognizes Dr. Costa’s outstanding contributions to the brain science of movement and learning that has yielded insights into Parkinson’s disease, autism and obsessive-compulsive disorder.

Disease October 9, 2019

Columbia Scientists Reverse Core Symptom of Schizophrenia in Adult Mice

Findings reveal potential new strategy for treating people diagnosed with schizophrenia.

Tools & Technology September 27, 2019

High-Speed Microscope Illuminates Biology at the Speed of Life

New SCAPE 2.0 system can serve as a critical tool to advance science and medicine.

Disease June 21, 2019

Chan Zuckerberg Initiative Awards $1.5M to Columbia Scientists

As part of Chan Zuckerberg Initiative's newly formed Seed Networks for the Human Cell Atlas, Columbia team will work to advance broad-scale efforts to treat spinal cord injury and disease.

News May 15, 2019

Mind Brain Behavior Symposium is a Meeting of Minds

Columbia’s Zuckerman Institute hosts gathering of leading neuroscientists from across the country

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