Disease

Scientists Identify Gene That First Slows, Then Accelerates, ALS in Mice

From the lab of Tom Maniatis, PhD, Columbia's Zuckerman Institute

Representative confocal microscope image of the ventral horn of the spinal cord from an ALS mouse. Several microglial cells (green) infiltrate the spinal cord as ALS disease progresses. Single molecule FISH detected IRF7 (an interferon-inducible gene) RNA molecules (red) in microglia and other cells (Credit: Valeria Gerbino/Maniatis lab/Columbia’s Zuckerman Institute).

A Mind to Discover

At Columbia’s Zuckerman Institute, we believe that understanding how the brain works — and gives rise to mind and behavior — is the most urgent and exciting challenge of our time. Led by Rui Costa, DVM, PhD, and Nobel laureates Richard Axel, MD and Eric Kandel, MD, we study critical aspects of the mind and brain, gaining insights that promise to benefit people and societies everywhere.

Our Science: We explore how the brain develops, performs, endures and recovers.

People

Transforming How We Image the Brain

Bringing her engineering and physics expertise to neuroscience, Professor Elizabeth Hillman, PhD, has developed a wide range of multi-scale in-vivo imaging methods including SCAPE microscopy for high-speed 3D imaging of neural activity.

Scientific Platforms: The tools, facilities and people that make our research possible.

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Apr 8 2020 8:30 am
Symposium

COVID-19 Virtual Symposium: April 8

Columbia University researchers and clinicians are invited to join these regular virtual symposia on COVID-19.

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ZUCKERMAN INSTITUTE IN THE NEWS

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Columbia Neuroscience Seminar Series

Sparking the conversations that drive science forward

Elaine Hsiao, PhD, Assistant Professor of Integrative Biology & Physiology at UCLA, speaks a recent seminar (Credit: Sirin Samman for Columbia's Zuckerman Institute)

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Our Mission

At Columbia's Zuckerman Institute, our mission is to decipher the brain. From effective treatments for disorders like Alzheimer’s and autism to advances in fields as fundamental as economics, the arts and law, the potential for humanity is staggering.

Jerome L. Greene Science Center (Credit: Frank Oudeman/Columbia University).

People

Cracking the Brain’s Code


Professor Stefano Fusi, PhD, wants to design technology inspired by the human brain. As a step toward this goal, he is using math to better understand how the brain itself computes information, especially as related to problem solving, reasoning and decision-making. Dr. Fusi’s work could lead to technological advances that have thus far remained beyond our reach.