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How are Adult and Newborn Mouse Brains Different?

From the lab of Elizabeth Hillman, PhD, Columbia's Zuckerman Institute

A rush of blood (red) to vessels in the brain, as revealed by new imaging techniques (Credit: Hillman lab / Columbia's Zuckerman Institute).

The human brain begins as a few mere cells.

Those cells multiply, again and again, to create a community of 100 billion cells, more than the number of stars in the observable universe. This transformation is nothing short of a biological miracle.

How do different brain cells become specialized and responsible for different tasks, from appreciating a sunset to typing an email? What guides the growth of nerve cells in the brain and body, helping them to form the 100 trillion connections that underlie every thought, memory, movement and sensation? How much can your brain remold itself during your early years, adulthood and in old age?

To understand how our brains develop, scientists at Columbia’s Zuckerman Institute start with simpler organisms and animals, including fruit flies, electric fish and rodents. Our research reveals each step of the genetic and molecular choreography that gives rise to a fully formed brain. What we uncover about our early years could inform fields ranging from education to medicine. Understanding how the brain grows could be the key to repairing damage from physical injury or disease.

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