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Could the Body’s Own Defense Against ALS Actually Drive Disease Progression?

From the lab of Tom Maniatis, PhD, Columbia's Zuckerman Institute

Differences in disease progression in spinal interneurons, a type of nerve cell that generally succumbs to ALS in later stages of disease. Left: Normal ALS models, showing protein aggregation (red/green) in spinal interneurons. Right: autophagy-suppressed ALS models, showing virtually no aggregation (Credit: Tom Maniatis/Columbia's Zuckerman Institute).

News from about

Tools & Technology June 16, 2017

Building the Tools to Revolutionize Brain Research

At the 2017 World Science Festival, scientists shared their insights into how technology is advancing what we can uncover about the brain — and how that knowledge stands to improve health and society

Tools & Technology December 12, 2016

Patterns Revealed in the Brain at Rest

Findings offer insight into long-standing scientific question; reinforce use of fMRI for studies of brain activity.

Tools & Technology November 8, 2016

Real-Time 3D Imaging of Living Brains

Leica Microsystems to develop SCAPE microscopy.

Learning & Memory July 7, 2016

Imaging Study in Mice Sheds Light on How the Brain Draws a Map

Scientists track brain-cell activity of mice in real time, gain insight into how the brain stores and organizes information

Tools & Technology June 21, 2016

How are Adult and Newborn Mouse Brains Different?

Findings reveal mismatch between neuronal activity and blood flow in the brains of newborn mice, shedding new light on how the growing brain feeds itself

Movement May 27, 2016

Tracing the Steps that Guide Movement

For Richard Mann, answers to some of biology’s biggest puzzles, such as how our brains direct our muscles to move, can be found in the tiniest of places.

Computation March 22, 2016

Teasing Signals from the Brain

Statistician John Cunningham examines how the complex communication between motor neurons gives rise to the elegant simplicity of our movements.

Tools & Technology March 15, 2016

Building the Tools to Reveal the Invisible

How a ‘hack’ to a high-powered microscope — and an innovative statistical technique — stands to change what we see when we peer inside the brain.

Learning & Memory March 10, 2016

Newborn Brain Cells Required for Memory

Columbia neuroscientists have described the activity of newly generated brain cells in awake mice and revealed the critical role these cells play in forming memories.

Tools & Technology January 21, 2016

A New Way to Trace Brain Circuits

These findings highlight an innovative feat of molecular engineering that allows the creation of a more complete map of the brain’s cellular circuits.