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Scientists Identify Gene That First Slows, Then Accelerates, ALS in Mice

From the lab of Tom Maniatis, PhD, Columbia's Zuckerman Institute

Representative confocal microscope image of the ventral horn of the spinal cord from an ALS mouse. Several microglial cells (green) infiltrate the spinal cord as ALS disease progresses. Single molecule FISH detected IRF7 (an interferon-inducible gene) RNA molecules (red) in microglia and other cells (Credit: Valeria Gerbino/Maniatis lab/Columbia’s Zuckerman Institute).

News from about

March 3, 2020

International Women's Day: Elizabeth Hillman's Magic Microscopes

This International Women's Day, meet Biomedical Engineer Elizabeth Hillman. She is inventing new kinds of microscopes that create 3D movies of life in action.

Disease February 6, 2020

Toxic Protein, Linked to Alzheimer’s and Other Diseases, Exposed in New Detail

Columbia-led team harnesses two powerful technologies to identify promising targets for diagnosing and treating neurodegenerative diseases.

Tools & Technology December 18, 2019

Curious Minds: How Can We See Living Nerve Cells in Action?

If you could see the brain at work in a living creature, imagine what you could discover about the biology’s most fundamental processes. For postdoctoral research scientist Wenze Li, PhD, and graduate student Rebecca Vaadia, this is not a dream, but reality.

Movement November 27, 2019

Why Do We Freeze When Startled? New Study in Flies Points to Serotonin

Columbia researchers uncover mechanism that produces the fly’s startle response, offers clues as to what may happen in our own bodies when we get startled.

The Senses October 21, 2019

How the Brain Dials Up the Volume to Hear Someone in a Crowd

Columbia-led study offers new insight into organization of brain’s listening center; provides roadmap for development of hearing-aid technologies inspired by the brain

Disease October 21, 2019

Rui Costa Elected to the National Academy of Medicine

Academy recognizes Dr. Costa’s outstanding contributions to the brain science of movement and learning that has yielded insights into Parkinson’s disease, autism and obsessive-compulsive disorder.

Tools & Technology September 27, 2019

High-Speed Microscope Illuminates Biology at the Speed of Life

New SCAPE 2.0 system can serve as a critical tool to advance science and medicine.

Tools & Technology September 18, 2019

Anthony Fitzpatrick Receives $2.84M to Decipher Origins of Brain Disorders

Funding will support combined use of recent Nobel Prize-winning technology with a powerful new imaging method; lays groundwork for detecting, treating underlying causes of Alzheimer’s, Parkinson’s and Lewy body dementia

Growth & Development August 29, 2019

A Biological ‘Rosetta Stone’ to Decipher How the Body is Built

International study reveals promising method for decoding the underlying genetic mechanisms that guide growth and development.

Disease June 21, 2019

Chan Zuckerberg Initiative Awards $1.5M to Columbia Scientists

As part of Chan Zuckerberg Initiative's newly formed Seed Networks for the Human Cell Atlas, Columbia team will work to advance broad-scale efforts to treat spinal cord injury and disease.

Zuckerman Institute In the News

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