At Columbia’s Zuckerman Institute Itamar Kahn, PhD, aims to understand how the brain gives rise to the astounding complex behaviors associated with high-order cognition. Dr. Kahn's research takes a cross-species comparative approach to study the organization of brain systems in the intact brain and identify potential mechanisms of disease in animal models and human patients. Over the past two decades a revolution in human brain research took place due to the availability of magnetic resonance imaging (MRI) methods allowing to evaluate the structure and function of the brain non-invasively. Dr. Kahn's research leverages these advances to ask mechanistic questions about brain circuits and behavior in small animals. The guiding principle driving this work is that developments in MRI in small animals in general, and in mice in particular, offer an opportunity to provide a translational bridge between mechanistic research in animal models and humans. Thus, by combining technological development of MRI methods to be used in the mouse with conceptual questions about brain connectivity and function in mouse and human we strive to explain the brain mechanisms associated with flexible behavior in humans.