This seminar will be held in the Jerome L. Greene Science Center on Columbia's Manhattanville campus (9th floor lecture hall). Columbia University's Intercampus Shuttle Service is the best way to travel between campuses.

Brain-wide fluctuations in local field potential oscillations reflect emergent network- level signals that mediate behavior. Cracking the code whereby these oscillations coordinate in time and space (spatiotemporal dynamics) to represent complex behaviors would provide fundamental insights into how the brain signals emotional pathology. Using machine learning, we discover a spatiotemporal dynamic network that predicts the emergence of depression- related behavioral dysfunction in mice subjected to chronic social defeat stress. Activity patterns in this network originate in prefrontal cortex and ventral striatum, relay through amygdala and ventral tegmental area, and converge in ventral hippocampus. This network is increased by acute threat, and it is also enhanced in three independent models of depression vulnerability. Finally, we demonstrate that this vulnerability network is biologically distinct from the networks that encode dysfunction after stress. Thus, we reveal a convergent mechanism through which depression vulnerability is mediated in the brain. We also demonstrate a novel strategy for linking mesoscale brain states to emotional behavior.

Kafui Dzirasa was born to Samuel and Abigail Dzirasa, who grew up as neighbors in an area outside of Accra, Ghana. His father came to the US in 1971 when he was accepted into the Civil Engineering Program at MIT, and his mother followed soon after completing a nursing degree in England. After graduation, his father went on to obtain an MBA from the Sloan School of Business. Kafui was born in Boston, MA in 1978, and grew up with his three brothers and a sister in Silver Spring.

Kafui Dzirasa is the first African American to complete a PhD in Neurobiology at Duke University. His research interests focus on understanding how changes in the brain produce neurological and mental illness, and his graduate work has led to several distinctions including: the Somjen Award for Most Outstanding Dissertation Thesis, the Ruth K. Broad Biomedical Research Fellowship, the UNCF·Merck Graduate Science Research Fellowship, and the Wakeman Fellowship. Kafui obtained an MD from the Duke University School of Medicine in 2009, and completed residency training in General Psychiatry in 2016.

Kafui is a product of the nationally renowned Meyerhoff Scholarship program at the University of Maryland Baltimore County (UMBC), where he was conference champion in the long jump, an Academic All-American, and Student Body president.

Kafui has served on the Board of Directors of the Student National Medical Association: a national organization dedicated to the eradication of health care disparities. Through his service as Chapter President, Region IV Director and National Internal Affairs Committee Chair, Kafui has participated in numerous programs geared towards exposing youth to science and technology, providing health education for underserved communities, and organizing clinics to screen for chronic diseases. Kafui received the Charles Johnson Leadership Award in 2007, and he was recognized as one of Ebony magazine’s 30 Young Leaders of the Future in February 2008. He has also been awarded the International Mental Health Research Organization Rising Star Award, the Sydney Baer Prize for Schizophrenia Research, and his laboratory was featured on CBS 60 Minutes in 2011. In 2016, he was awarded the inaugural Duke Medical Alumni Emerging Leader Award and the Presidential Early Career Award for Scientists and Engineers: The Nation’s highest award for scientists and engineers in the early stages of their independent research careers. In 2017, he was recognized as 40 under 40 in Health by the National Minority Quality Forum, and the Engineering Alumni of the Year from UMBC.

Kafui has served as an Associate Scientific Advisor for the journal Science Translational Medicine, and he was a member of the Congressional-mandated Next Generation Research Initiative. He currently serves on the Editorial Advisory Board for TEDMED, and the Advisory committee for the NIH Director for the BRAIN Initiative.

Kafui is an Associate Professor at Duke University with appointments in the Departments of Psychiatry and Behavioral Sciences, Neurobiology, Biomedical Engineering, and Neurosurgery. His ultimate goal is to combine his research, medical training, and community experience to improve outcomes for diverse communities suffering from Neurological and Psychiatric illness.

Those who wish to meet the speaker during their visit should contact Bianca Marlin. For general inquiries please contact [email protected].

The Columbia Neuroscience Seminar series is a collaborative effort of Columbia's Zuckerman Institute, the Department of Neuroscience, the Doctoral Program in Neurobiology and Behavior and the Columbia Translational Neuroscience Initiative, and with support from the Kavli Institute for Brain Science.