Martin Kampmann, PhD

Professor, Department & Biochemistry Biophysics and Institute for Neurogenerative Diseases

UCSF

Host(s): Hynek Wichterle (Faculty) 

Uncovering mechanisms of neurodegeneration by CRISPR-based functional genomics

The Kampmann lab develops functional genomics technologies to understand cellular and molecular mechanisms of human brain disease, and to discover new therapeutic strategies. Our CRISPR-based functional genomics platform in human iPSC-derived neurons and glia enables genome-wide modifier screens of disease-relevant cell biology in patient-derived cells. Using this approach, we are asking what controls cell-type selective vulnerability to tau aggregation and toxicity, we are identifying mechanisms regulating disease-associated states of astrocytes and microglia, and characterizing how cellular interactions are altered in these disease states. A new research direction is the identification of mechanisms of synapse loss in neurodegeneration.

Relevant Publications:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

Venue Information:

Speaker Location: Jerome L. Greene Science Center, Kavli Auditorium, 9th Floor Lecture Hall

The Columbia Neuroscience Seminars have been organized to help build community and collaboration among researchers interested in this broad field across campus. The in-person activities, including the talks, provide meaningful interactions for the speakers, many of whom have traveled a long way to visit Columbia. However, if you are a Columbia researcher on another campus and are unable to attend the talk at the Jerome L. Greene Science Center, please email [email protected] at least 48 hours in advance to request an individual, one-time Zoom link (livestream only, no Q&A). 

If you have a short- or long-term accommodation request (medical issue, travel, other concerns, etc.), or any other questions, please also reach out to [email protected].

Tuesdays@10 is a signature Zuckerman Institute initiative that aims to expose researchers at all levels to high-quality science and stimulate scientific discourse. The speakers featured in this series represent various fields and techniques in neuroscience, and include invited guests of the Columbia Neuroscience Seminars, the Zuckerman Institute's Local Circuits Affiliates Program, and other special seminar series through a combined, collaborative effort of one or more of the following: Columbia's Zuckerman Institute, the Center for Precision Psychiatry, the Department of Neuroscience, the Doctoral Program in Neurobiology and Behavior and the Columbia Translational Neuroscience Initiative, and with support from the Kavli Institute for Brain Science. 

More information and a full schedule can be found here.