Anne Brunet, PhD

Michele and Timothy Barakett Endowed Professor

Co-director of the Paul F. Glenn Laboratories for the Biology of Aging

Stanford University School of Medicine

Host(s): Kapil Ramachandran (Faculty), Bianca Corjic (Postdoc)

Understanding and modeling aging

Understanding and modeling aging Anne Brunet, Stanford University Aging is associated with a decline in tissue function and the onset of a constellation of diseases. We are interested in understanding aging, with a particular focus on brain aging. Because aging is complex, we use organisms with diverse lifespans – the worm C. elegans, the African killifish, the mouse, and cells from mice and humans. We are interested in identifying epigenetic and metabolic pathways involved in delaying aging in response to external stimuli, including nutrients and the opposite sex. Our lab is also interested in using mouse models to address complex questions about mammalian aging, notably the regulation of regenerative neural stem cells and their progeny during aging. Finally, we are pioneering the naturally short-lived African killifish as a new model to identify principles underlying vertebrate aging and “suspended animation”. We hope that these discoveries will identify new strategies to delay, suspend, or even reverse aspects of aging and age-related diseases.

Tuesdays@10 is a signature Zuckerman Institute initiative that aims to expose researchers at all levels to high-quality science and stimulate scientific discourse. The speakers featured in this series represent various fields and techniques in neuroscience, and include invited guests of the Columbia Neuroscience Seminars, the Zuckerman Institute's Local Circuits Affiliates Program, and other special seminar series through a combined, collaborative effort of one or more of the following: Columbia's Zuckerman Institute, the Center for Precision Psychiatry, the Center for Theoretical Neuroscience, the Department of Neuroscience, the Doctoral Program in Neurobiology and Behavior and the Columbia Translational Neuroscience Initiative, and with support from the Kavli Institute for Brain Science. 

More information and a full schedule can be found here.