Columbia University in the City of New York

May 9, 20234:00 pm
Seminar

Columbia Neuroscience Seminar - Natalia De Marco Garcia

GABAergic circuit assembly in the somatosensory cortex

May 9th, 4:00 pm – 5:00 pm at the Jerome L. Greene Science Center (9th floor lecture hall)

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Natalia De Marco Garcia, PHD
Associate Professor of Neuroscience and Mind Research
Janelia Research Campus Weill Cornell Medical College


GABAergic circuit assembly in the somatosensory cortex
 

During neonatal development, sensory cortices generate activity patterns shaped by both sensory experience and intrinsic influences. How these patterns contribute to the assembly of neuronal circuits is not clearly understood. Using in vivo calcium imaging in young mouse pups, we show that spatially segregated assemblies of interneuron and pyramidal cells are already evident at neonatal stages. In this talk, I will cover recent work from my lab indicating that GABAergic inputs restrict pyramidal cell co-activation to balance the number of interneurons integrating into maturing cortical networks. In addition, I will discuss how imaging approaches including longitudinal 2-photon and wide-field calcium imaging can be used to reveal the link between genetic predispositions for neurodevelopmental disorders and aberrant functional connectivity during a critical window of development.


Host Information: Edmund Au ([email protected])

 

The Columbia Neuroscience Seminar series is a collaborative effort of Columbia's Zuckerman Institute, the Department of Neuroscience, the Doctoral Program in Neurobiology and Behavior and the Columbia Translational Neuroscience Initiative, and with support from the Kavli Institute for Brain Science.

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