Bassem Hassan, PhD
Team Leader and Scientific Director
Paris Brain Institute
Temporal emergence of wiring specificity
The formation synaptic connectivity diagrams during development requires rapid local regulation of axonal organelles and the cytoskeleton. Whether this fundamental and conserved aspect of neuronal cell biology is orchestrated by a dedicated developmental program is unknown. I will describe our efforts towards deconstructing the temporal sequence of events that link developmental genetic programs to local basic cell biology to allow the emergence of highly stereotyped circuit diagrams from temporally orchestrated, fundamentally stochastic, biological processes.
Relevant Publications:
A neurodevelopmental origin of behavioral individuality in the Drosophila visual system
Probalistic axon targeting dynamics lead to individualized brain wiring
Host(s): Wes Grueber (Faculty) and Nova Qi (Graduate Student)
Please contact [email protected] with any questions.
This event will be in-person only and will not offer a Zoom option.
Open only to Columbia University and Columbia University Affiliates.
Speaker Location: Jerome L. Greene Science Center, 9th Floor Lecture Hall
Live-stream Location: CUIMC, Neurological Institute First Floor Auditorium
Tuesdays@10 is a signature Zuckerman Institute initiative that aims to expose researchers at all levels to high-quality science and stimulate scientific discourse. The speakers featured in this series represent various fields and techniques in neuroscience, and are either external to Columbia (Columbia Neuroscience Seminars and Special Seminars) or are Columbia faculty members (Local Circuits) invited through a combined, collaborative effort of one or more of the following: Columbia's Zuckerman Institute, the Department of Neuroscience, the Doctoral Program in Neurobiology and Behavior and the Columbia Translational Neuroscience Initiative, and with support from the Kavli Institute for Brain Science.
More information and a full schedule can be found here.