The blood-brain and blood-cerebrospinal fluid barriers were originally framed as selective gateways that limited interactions between cells of the nervous system and peripheral tissues. More recently, the concept of an impenetrable 'barrier' has ceded ground to the idea of a dynamically regulated gate that supports bidirectional interactions between circulating factors and cells in the brain parenchyma. In obesity, signaling between fat and brain disrupts homeostatic control circuits, creating a dysfunctional feedback network. Adipose-derived signals also exert feedforward control over circuits in the medial temporal lobe, leading to memory deficits in rodents and humans. Storage of excess energy in visceral or subcutaneous adipose tissue has distinct (and often opposing) consequences for metabolism and immunity, and in this seminar, I will present recent work on immunological regulation of hippocampal function by signals from different adipose depots in mouse models.
Those wishing to meet the speaker should contact Latasha Wright.
The Columbia Neuroscience Seminar series is a collaborative effort of Columbia's Zuckerman Institute, the Department of Neuroscience, the Doctoral Program in Neurobiology and Behavior and the Columbia Translational Neuroscience Initiative, and with support from the Kavli Institute for Brain Science.