Join us in celebrating Tom Maniatis’ 80th Birthday. Tom and his students and post-doctoral trainees pioneered the development of genomic technology, and its application to the study of the molecular mechanisms of gene regulation. Their cloning of the human β-globin gene cluster in 1978  provided the means of isolating genes and identifying mutations that result in defects in transcription and RNA splicing associated with β-thalassemia, and to advances in the understanding of the mechanisms of transcription and RNA splicing. Their studies of the human β-interferon gene led to the discovery of multi-protein enhancer complexes (enhanceosomes) that regulate gene expression, and the role of the ubiquitin proteosome pathway in the activation of innate immunity. This, in turn, led to important insights into the mechanisms by which autophagy and neuroinflammation accelerate disease progression in ALS. Most recently, the lab has focused on the complex genomic organization and expression of the protocadherin gene cluster, which has led to insights into mechanisms by which complex “barcodes” are generated on the surface of all neurons, and how clustered protocadherins function in neural circuit assembly. Former members of the Maniatis lab will present their recent work.
 

Schedule of speakers:

9:00 - 9:05a Welcome Remarks

9:05 – 9:15am Richard Axel
 

RNA

9:15 - 9:35a Anne Ephrussi, EMBL

9:35 - 9:55a Kristen Lynch, UPenn

9:55 - 10:15a Jane Wu, Northwestern
 

Coffee Break 10:15 - 10:45

Disease

10:45 - 11:05a Valeria Gerbino, Milan

11:05 - 11:35a Richard Treisman, Crick Institute

11:35 - 11:55a Mary Lynn Hedley, Broad Institute

11:55a - 12:15p Ted Abel, University of Iowa
 

Lunch Break 12:15 – 1:00p
 

1:00 – 1:10p Roy Vagelos
 

Immunity

1:10 - 1:30p James Chen, UT Southwestern

1:30 - 1:50p Ben tenOever, NYU Langone Health

1:50 - 2:10p Olie Rando, UMass

2:10 - 2:30p Kevin Monahan, Rutgers University
 

Coffee Break 2:30 - 2:50p
 

Genomics

2:50 - 3:20p Argiris Efstratiadis, Academy of Athens

3:20 - 3:40p Rick Myers, HudsonAlpha

3:40 - 4:00p Bosilijika Tasic, Allen Institute

4:00 - 4:20p Daniele Canzio, UCSF

4:20 - 4:40p Silas Maniatis, NYGC
 

Concluding Remarks: Charles Zuker and final word by Tom Maniatis 
 

5:00pm: Networking reception in Atrium at The Forum