Shantanu Jadhav, PhD

Professor, Neuroscience Program, Department of Psychology and Volen Center for Complex Systems

Brandies University

Host(s): Joshua Gordon (Faculty), Richa Sirmaur (Postdoc)

Neural mechanisms in hippocampal - prefrontal networks for memory and cognition

My lab uses rodent models to investigate the neural basis of memory and cognition in the mammalian brain. We combine behavior and high-density in vivo electrophysiological recordings to study coordinated activity in distributed neural circuits, in particular the interactions between the hippocampus, the brain’s memory hub, and the prefrontal cortex, the brain’s executive hub. I will present recent findings that establish prominent neurophysiological activity patterns in hippocampal- prefrontal networks that support learning and memory-guided decision making. These activity patterns enable networks to process, store and retrieve information in a state-dependent manner and at multiple timescales to mediate memory-guided behavior, highlighting a critical link between neural dynamics and cognition.

Relevant Publications: 
Dynamics of Awake Hippocampal-Prefrontal Replay for Spatial Learning and Memory-Guided Decision Making
Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits

Tuesdays@10 is a signature Zuckerman Institute initiative that aims to expose researchers at all levels to high-quality science and stimulate scientific discourse. The speakers featured in this series represent various fields and techniques in neuroscience, and include invited guests of the Columbia Neuroscience Seminars, the Zuckerman Institute's Local Circuits Affiliates Program, and other special seminar series through a combined, collaborative effort of one or more of the following: Columbia's Zuckerman Institute, the Center for Precision Psychiatry, the Center for Theoretical Neuroscience, the Department of Neuroscience, the Doctoral Program in Neurobiology and Behavior and the Columbia Translational Neuroscience Initiative, and with support from the Kavli Institute for Brain Science. 

More information and a full schedule can be found here.