Columbia University’s Mortimer B. Zuckerman Mind Brain Behavior Institute (the Zuckerman Institute) brings together researchers to explore aspects of mind and brain, through the exchange of ideas and active collaboration. The Zuckerman Institute’s home will be the Jerome L. Greene Science Center on Columbia’s new Manhattanville campus. Situated in the heart of Manhattan, at full capacity the Zuckerman Institute will house approximately 47 laboratories employing a broad range of interdisciplinary approaches to transform our understanding of the mind and brain. In this highly collaborative environment, labs work together to gain critical insights into human health by exploring how the brain develops, performs, endures and recovers from trauma or disease.
A lab within the Zuckerman Institute seeks an Associate Research Scientist (ARS) to investigate the molecular diversity of cell types and cell states in primary motor cortex, a region necessary for motor skill learning. We will use state-of-the-art technologies to uncover the molecular profiles of primary motor cortex during motor skill learning. The successful candidate will employ a novel approach that tags active cells in mouse motor cortex during a forelimb task and allows for their isolation and single-cell transcriptional profiling, allowing for the examination of cell-type specific enrichment over learning. We will then focus on cell types identified as enriched at late learning and map their brain wide projection pattern, examine their dynamics and engagement in motor cortex over learning, and manipulate their activity using optogenetics to causally test how these circuits modulate motor learning.
The ideal candidate will have expertise in rodent anatomy, viral and RNA-sequencing methods, operant behavioral, and strong in vivo imaging skills, as well as superior motivation, drive and demonstrated aptitude for research.
M.D., PhD, or doctorate in related field.
Strong candidates will be interested and focused on interdisciplinary work.